Bactiv Oral Suspension Dosage/Direction for Use

The dosage of amoxicillin/clavulanic acid powder for oral suspension depends on the age, weight and renal function of the particular patient, on the severity and the site of the infection and on the suspected or demonstrated causative agents.
The single dose should be taken at regular intervals throughout the day ideally at 12 hour intervals.
Usual recommended daily dosage for children aged two months to 12 years: 25/3.6 mg/kg/day in mild to moderate infections (skin and soft tissue infections).
45/6.4 mg/kg/day in more severe infections (otitis media, sinusitis and lower respiratory tract infections).
There is no clinical information on patients under 2 months of age. Therefore, dose recommendations cannot be given to this patient group.
Dosage recommendations according to body weight: 80 mg oral suspension (1 mL oral suspension = 80 mg amoxicillin). (See Table 4.)

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Usual recommended daily dosage for adults: 1,760 mg per day (11.0 mL twice daily).
Dosage in renal functional impairment: The dose should be reduced in patients with renal function impairment depending on the severity of the impairment and the patient's weight.
Amoxicillin/clavulanic acid powder for oral suspension should only be used in patients with a GFR >30 mL/min.
Dosage in hepatic functional impairment: Administer with caution. The liver function should be monitored at regular intervals. The experience in the use of the product in hepatic insufficiency is not adequate in order to give dose recommendations.
Method of administration: Amoxicillin/clavulanic acid is recommended to be taken at the start of meals to reduce any possible gastrointestinal discomfort.
Duration of administration: As a rule, amoxicillin/clavulanic acid powder for oral suspension is administered for a further 3 to 4 days after improvement/regression of the symptoms and should be continued, however, for at least the generally recommended minimum period of treatment. Treatment should not be extended beyond 14 days without review.
As a precaution, therapy over at least 10 days is indicated in the treatment of infections with β-hemolytic streptococci in order to guard against late complications (e.g. rheumatic fever, glomerulonephritis).